In recent decades, oxidative stress has been linked to premature aging and the onset of some chronic degenerative diseases. The importance that these mechanisms have for health has awakened great interest in substances capable of controlling it. For this reason, we would like to talk to you about this subject in detail.
What is oxidative stress?
If one molecule is oxidized, it is because another molecule has been reduced, and all these reactions are known as redox processes. Under normal conditions, they are maintained in equilib rium and are part of normal physiology.
They are characterized by electrons being transferred from one substance to another, which then becomes negatively charged. Since we live in an oxygen-rich environment, these charged molecules are part of the metabolism.
What are reactive oxygen species?
In these processes some molecules with toxic potential are generated, which contain oxygen and are negatively charged. They are called reactive oxygen species, ROS for short, and have several functions within cells: they are involved in DNA transcription, cell division and protein phosphorylation.
These very reactive and small molecules include oxygen ions, superoxide ion, hydroxyl ion, peroxides and free radicals. If they accumulate inside the cells, they massively oxidize other substances and degrade them, thus losing their functions.
Some exogenous factors are capable of accelerating these damaging processes, such as sedentary lifestyles, overweight, smoking, pollution and excessive exposure to sunlight. As a whole, they alter the redox balance, generate an excess of ROS and, thus, a high intracellular oxidative activity, which damages the cells.
Thus, the physiological antioxidant system and cellular repair, two natural processes that protect tissues, are overcome. Consequently, an imbalance arises between oxidative and antioxidant reactions, which is called oxidative stress.
The consequence is a destructive effect on proteins, DNA, carbohydrates and lipids. Organs suffer chronic deterioration and degenerative diseases appear.
What are the consequences?
This imbalance is a generalized problem and, for that reason, has a negative impact on the functioning of many organs. The most directly related diseases are:
- Premature aging.
- Arterial hypertension.
- Senile cataract.
- Acute renal failure.
ROS and joint pain
The tissues that make up the joints are no exception. In this case, mechanical factors such as overweight, trauma, joint overload and age continue to play an important role. However, redox imbalance is a determining factor in the onset of arthritis and osteoarthritis.
Within this field, a study conducted with patients suffering from rheumatoid arthritis had conclusive findings. Specifically, the presence of marker molecules for oxidative stress was determined.
The most common symptom of these two diseases is chronic joint pain related to movement, which is attenuated by rest. In addition, other associated signs are present, such as joint stiffness, swelling and loss of function.
ROS affect various joint structures, resulting in damage that, in many cases, is irreversible. Chondrocytes are the cells in charge of producing and repairing cartilage and the redox imbalance reduces this capacity; in the long term, it causes the death of these cells.
Something similar happens with the synovial cells, which stop producing synovial fluid, a natural lubricant of the joints. These processes contribute to accelerated wear and tear of the joints and increased bone pain.
Degenerative changes also occur in the subchondral bone, i.e. the bone immediately below the cartilage. The cells responsible for generating, repairing and remodeling bone tissue do not function properly and their activity decreases.
How do antioxidants help to maintain balance and avoid the consequences?
Antioxidants, also called free radical scavengers, are substances capable of slowing down or alleviating cell damage caused by ROS. You can get them from the diet, as they are found in various plant foods.
The intake of substances with an antioxidant effect reduces these risks by several mechanisms. Among the most important are the decomposition of peroxides and the inhibition of enzymes involved in cell toxicity. They also function as hydrogen or electron donors, neutralizing charged ions.
In this sense, Olimina3® is a formula specifically created to relieve joint pain and associated inflammation. Contains Hytolive®, an exclusive patented compound of extra virgin olive oil polyphenols. In addition, it contains curcumin and omega-3 fatty acids, which also have antioxidant power.
In any case, plant-derived compounds that help control oxidative stress are beneficial to the health and integrity of your joints. Therefore, they take care of your quality of life. Visit our website to learn more about Olimina3® and its positive effects!